Protein "Chameleon" Colors Long-Term Memory

Researchers at Rice University and the University of Texas Health Science Center at Houston have uncovered new insights into the role of the protein CPEB3 in long-term memory formation. CPEB3, described as a "chameleon-like" protein, interacts with actin-binding domains in neurons, forming stable aggregates that may store memory-related information. The study highlights a positive feedback loop between actin structures in dendritic spines and CPEB3, suggesting that these interactions contribute to memory retention. Additionally, the protein SUMO appears to regulate when and how CPEB3 binds to actin, influencing its function in neural plasticity. The findings provide a deeper understanding of the molecular mechanisms underlying memory storage and could have implications for neurological research.

Citation

Williams, M. (2020). Protein 'chameleon' colors long-term memory. Phys.org. https://phys.org/news/2020-08-protein-chameleon-long-term-memory.html